An evil hairless cat (Bette Midler) going by the name of Kitty Galore hatches a plan for world domination that would have dogs turn on their owners thus allowing for a world of cat domination with her as dictator. To this end, two dogs (James Marsden, Nick Nolte), a cat (Christina Applegate) and a pigeon (Katt Williams) reluctantly join forces to stop the evil Kitty Galore! A long belated sequel to the 2001 CATS AND DOGS, this family friendly, heavily CGI'd comedy is harmless enough but never manages to establish a comedic rhythm, instead it's all over the place. If it shoots enough cat and dog jokes at you, it's bound to hit a mark once in awhile. But the film reaches inspiration only twice. The opening credits are a witty parody of and homage to Maurice Binder's title credits to the James Bond films, with leaping felines instead of nude female silhouettes, dogs on bones instead of nudes on gun barrels and there's even a Shirley Bassey song accompanying it. The other is an amusing parody of SILENCE OF THE LAMBS with Sean Hayes (Mr. Tinkles of the 2001 film) as a Hannibal Lecter like cat. The cast includes Roger Moore, Michael Clarke Duncan and Wallace Shawn as felines and Neil Patrick Harris and Joe Pantoliano as dogs with Chris O'Donnell representing the human species.